GSK583 is a Highly Potent and Selective Inhibitor of RIP2 Kinase (RIP2K bing IC50=5 nM; rat in vivo PD IC50 = 50 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | GSK583 |
Iupac 化学名称 | GSK583 |
同义词 | GSK 583; GSK-583 |
英文同义词 | GSK 583; GSK-583 |
分子式 | C20H19FN4O2S |
分子量 | 398.4564 |
InChiKey | |
InChi | |
Cas号 | 1346547-00-9 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |