GTS-21, also known as DMBX-A, is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the 42 and 7 subtypes, but activates only the 7 to any significant extent. Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic[4] and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease, nicotine dependence,[10] and, most significantly, for schizophrenia. (https://en.wikipedia.org/wiki/GTS-21).
仅供研究使用。 我们不向患者出售。
化学信息
名称 | GTS-21 |
Iupac 化学名称 | GTS-21 |
同义词 | GTS 21; GTS21; DMBX-A |
英文同义词 | GTS 21; GTS21; DMBX-A |
分子式 | C19H20N2O2 |
分子量 | 308.381 |
Smile | COc1ccc(c(c1)OC)/C=C/2\CCCN=C2c3cccnc3.Cl.Cl |
InChiKey | BXKYFUGAAFLYJL-BXGYHSFXSA-N |
InChi | InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;; |
Cas号 | 156223-05-1 |
MDL | MFCD00941364 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |