GlyH-101 is a CFTR inhibitor (cystic fibrosis transmembrane conductance regulator). GlyH-101 is a glycine hydrazide that has been shown to block CFTR channels. GlyH-101 blocked I(Cl.PKA) in a concentration- and voltage-dependent fashion (IC(50) at +100 mV=0.3 Â 1.5 M and at -100 mV=5.1 Â 1.3 M). GlyH-101 blocks the open pore of cardiac CFTR channels at an electrical distance of 0.15 Â 0.03 from the external membrane surface.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | GlyH-101 |
Iupac 化学名称 | GlyH-101 |
同义词 | GlyH101; GlyH 101 |
英文同义词 | GlyH101; GlyH 101 |
分子式 | C19H15Br2N3O3 |
分子量 | 493.15 |
Smile | c1ccc2cc(ccc2c1)NCC(=O)N/N=C/c3cc(c(c(c3O)Br)O)Br |
InChiKey | RMBDLOATEPYBSI-NUGSKGIGSA-N |
InChi | InChI=1S/C19H15Br2N3O3/c20-15-8-13(18(26)17(21)19(15)27)9-23-24-16(25)10-22-14-6-5-11-3-1-2-4-12(11)7-14/h1-9,22,26-27H,10H2,(H,24,25)/b23-9+ |
Cas号 | 328541-79-3 |
MDL | MFCD01532954 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |