IITZ-01
IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor. IITZ-01 enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy. IITZ-01 exhibited more than 10-fold potent autophagy inhibition along with 12- to 20-fold better cytotoxic action than CQ. IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity and awaits further preclinical development as potential anticancer therapeutic.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | IITZ-01 |
|---|---|
| Iupac 化学名称 | N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine |
| 同义词 | IITZ-01; IITZ 01; IITZ01; Autophagy inhibitor IITZ-01; |
| 英文同义词 | IITZ-01; IITZ 01; IITZ01; Autophagy inhibitor IITZ-01; |
| 分子式 | C26H23FN8O |
| 分子量 | 482.5234 |
| Smile | FC1=CC=C(NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=CC=CC=C6N5)C=C4)=N2)C=C1 |
| InChiKey | XGEDDGLPNSLBFE-UHFFFAOYSA-N |
| InChi | InChI=1S/C26H23FN8O/c27-18-7-11-20(12-8-18)29-25-32-24(33-26(34-25)35-13-15-36-16-14-35)28-19-9-5-17(6-10-19)23-30-21-3-1-2-4-22(21)31-23/h1-12H,13-16H2,(H,30,31)(H2,28,29,32,33,34) |
| Cas号 | 1807988-47-1 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Guntuku L, Gangasani JK, Thummuri D, Borkar RM, Manavathi B, Ragampeta S,
Vaidya JR, Sistla R, Vegi NGM. IITZ-01, a novel potent lysosomotropic autophagy
inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer
in vitro and in vivo. Oncogene. 2019 Jan;38(4):581-595. doi:
10.1038/s41388-018-0446-2. Epub 2018 Aug 30. PubMed PMID: 30166591.
