ISX-9 is a neurogenic agent. Isx-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. Isx-9 also improves hippocampal function, enhancing memory in the Morris water maze. Notably, Isx-9 enhances neurogenesis and memory without detectable increases in cellular or animal activity or vascularization. Isx-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2, revealing a novel cell-intrinsic molecular pathway regulating adult neurogenesis.
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化学信息
名称 | ISX-9 |
Iupac 化学名称 | ISX-9 |
同义词 | Isoxazole 9 |
英文同义词 | Isoxazole 9 |
分子式 | C11H10N2O2S |
分子量 | 234.27 |
Smile | c1cc(sc1)c2cc(no2)C(=O)NC3CC3 |
InChiKey | SYENTKHGMVKGAQ-UHFFFAOYSA-N |
InChi | InChI=1S/C11H10N2O2S/c14-11(12-7-3-4-7)8-6-9(15-13-8)10-2-1-5-16-10/h1-2,5-7H,3-4H2,(H,12,14) |
Cas号 | 832115-62-5 |
MDL | MFCD04133937 |
相关CAS号 | |
外观性状 | 类白色至白色固体 |
纯度 | 98% |
存储 | 短期可在0-4度保存,数天至数月;长期可在-20度保存三年。 |
可溶性 | 可溶于DMSO |
处理方式 | |
运输条件 | 可在常温下运输 |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |