IU1 is a reversible and specific inhibitor of proteasome-associating Usp14. It does not inhibit other deubiquitinating enzymes of the 26S proteasome. It partially inhibits the ubiquitin chain trimming activity of the 26S proteasome, which could function to stimulate the degradation of some proteasomal substrates.
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名称 | IU1 |
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Iupac 化学名称 | 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone |
同义词 | IU1 |
英文同义词 | IU1 |
分子式 | C18H21FN2O |
分子量 | 300.37 |
Smile | CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3 |
InChiKey | JUWDSDKJBMFLHE-UHFFFAOYSA-N |
InChi | InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3 |
Cas号 | 314245-33-5 |
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