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Icosapent ethyl

编号: 24045
Cas号: 86227-47-6
纯度: 98% Min.

 Icosapent ethyl is used for the treatment of hypertriglyceridemia.

仅供研究使用。 我们不向患者出售。

化学信息

名称Icosapent ethyl
Iupac 化学名称(all-Z)-5,8,11,14,17-Icosapentaenoic acid ethyl ester
同义词Icosapent ethyl;icosapent ethyl ester
英文同义词Icosapent ethyl;icosapent ethyl ester
分子式C22H34O2
分子量330.50
SmileCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCC)=O
InChiKeySSQPWTVBQMWLSZ-AAQCHOMXSA-N
InChiInChI=1S/C22H34O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h5-6,8-9,11-12,14-15,17-18H,3-4,7,10,13,16,19-21H2,1-2H3/b6-5-,9-8-,12-11-,15-14-,18-17-
Cas号86227-47-6
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式Refer to MSDS
运输条件可以在室温下进行运输。
海关编码2934200090
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Braeckman RA, Stirtan WG, Soni PN. Effects of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) on Pharmacokinetic Parameters of Rosiglitazone in Healthy Subjects. Clin Pharmacol Drug Dev. 2015 Mar;4(2):143-148. Epub 2014 Dec 3. PubMed PMID: 26097794; PubMed Central PMCID: PMC4467261.

2: Kim ES, McCormack PL. Icosapent ethyl: a review of its use in severe hypertriglyceridemia. Am J Cardiovasc Drugs. 2014 Dec;14(6):471-8. doi: 10.1007/s40256-014-0099-7. Review. PubMed PMID: 25428605.

3: Ballantyne CM, Bays HE, Philip S, Doyle RT Jr, Braeckman RA, Stirtan WG, Soni PN, Juliano RA. Icosapent ethyl (eicosapentaenoic acid ethyl ester): Effects on remnant-like particle cholesterol from the MARINE and ANCHOR studies. Atherosclerosis. 2016 Oct;253:81-87. doi: 10.1016/j.atherosclerosis.2016.08.005. Epub 2016 Aug 20. PubMed PMID: 27596132.

4: Braeckman RA, Stirtan WG, Soni PN. Effect of concomitant icosapent ethyl (eicosapentaenoic acid ethyl ester) on the pharmacokinetics of atorvastatin. Clin Drug Investig. 2015 Jan;35(1):45-51. doi: 10.1007/s40261-014-0252-8. PubMed PMID: 25471740; PubMed Central PMCID: PMC4281350.

5: Ballantyne CM, Bays HE, Braeckman RA, Philip S, Stirtan WG, Doyle RT Jr, Soni PN, Juliano RA. Icosapent ethyl (eicosapentaenoic acid ethyl ester): Effects on plasma apolipoprotein C-III levels in patients from the MARINE and ANCHOR studies. J Clin Lipidol. 2016 May-Jun;10(3):635-645.e1. doi: 10.1016/j.jacl.2016.02.008. Epub 2016 Feb 23. PubMed PMID: 27206952.

6: Kedia AW, Lynch E. Effects of switching from omega-3-acid ethyl esters to icosapent ethyl in a statin-treated patient with elevated triglycerides. Postgrad Med. 2015;127(8):869-73. doi: 10.1080/00325481.2015.1100086. Epub 2015 Oct 9. PubMed PMID: 26453247.

7: Bays HE, Ballantyne CM, Braeckman RA, Stirtan WG, Doyle RT Jr, Philip S, Soni PN, Juliano RA. Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester): Effects Upon High-Sensitivity C-Reactive Protein and Lipid Parameters in Patients With Metabolic Syndrome. Metab Syndr Relat Disord. 2015 Aug;13(6):239-47. doi: 10.1089/met.2014.0137. Epub 2015 Apr 20. PubMed PMID: 25893544.

8: Nelson SD, Munger MA. Icosapent ethyl for treatment of elevated triglyceride levels. Ann Pharmacother. 2013 Nov;47(11):1517-23. doi: 10.1177/1060028013504079. Epub 2013 Nov 5. Review. PubMed PMID: 24259598.

9: Fares H, Lavie CJ, DiNicolantonio JJ, O'Keefe JH, Milani RV. Icosapent ethyl for the treatment of severe hypertriglyceridemia. Ther Clin Risk Manag. 2014 Jun 24;10:485-92. doi: 10.2147/TCRM.S36983. eCollection 2014. Review. PubMed PMID: 25028554; PubMed Central PMCID: PMC4077874.

10: Bays HE, Ballantyne CM, Doyle RT Jr, Juliano RA, Philip S. Icosapent ethyl: Eicosapentaenoic acid concentration and triglyceride-lowering effects across clinical studies. Prostaglandins Other Lipid Mediat. 2016 Sep;125:57-64. doi: 10.1016/j.prostaglandins.2016.07.007. Epub 2016 Jul 11. PubMed PMID: 27418543.

11: Ballantyne CM, Braeckman RA, Soni PN. Icosapent ethyl for the treatment of hypertriglyceridemia. Expert Opin Pharmacother. 2013 Jul;14(10):1409-16. doi: 10.1517/14656566.2013.798645. Epub 2013 May 24. PubMed PMID: 23701295.

12: Castaldo RS. A retrospective case series of the lipid effects of switching from omega-3 fatty acid ethyl esters to icosapent ethyl in hyperlipidemic patients. Postgrad Med. 2014 May;126(3):268-73. doi: 10.3810/pgm.2014.05.2775. PubMed PMID: 24977343.

13: Bays HE, Ballantyne CM, Braeckman RA, Stirtan WG, Soni PN. Icosapent ethyl, a pure ethyl ester of eicosapentaenoic acid: effects on circulating markers of inflammation from the MARINE and ANCHOR studies. Am J Cardiovasc Drugs. 2013 Feb;13(1):37-46. doi: 10.1007/s40256-012-0002-3. PubMed PMID: 23325450; PubMed Central PMCID: PMC3572383.

14: Castaldo RS. Switching statin-treated patients from fenofibrate to the prescription omega-3 therapy icosapent ethyl: a retrospective case series. Drugs Ther Perspect. 2016;32:162-169. Epub 2016 Mar 8. PubMed PMID: 27065746; PubMed Central PMCID: PMC4801984.

15: Ballantyne CM, Braeckman RA, Bays HE, Kastelein JJ, Otvos JD, Stirtan WG, Doyle RT Jr, Soni PN, Juliano RA. Effects of icosapent ethyl on lipoprotein particle concentration and size in statin-treated patients with persistent high triglycerides (the ANCHOR Study). J Clin Lipidol. 2015 May-Jun;9(3):377-83. doi: 10.1016/j.jacl.2014.11.009. Epub 2014 Nov 29. PubMed PMID: 26073397.

16: Braeckman RA, Manku MS, Bays HE, Stirtan WG, Soni PN. Icosapent ethyl, a pure EPA omega-3 fatty acid: effects on plasma and red blood cell fatty acids in patients with very high triglyceride levels (results from the MARINE study). Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):195-201. doi: 10.1016/j.plefa.2013.07.005. Epub 2013 Aug 1. PubMed PMID: 23992935.

17: Reddy KJ, Chowdhury S. Improving lipids with prescription icosapent ethyl after previous use of fish oil dietary supplements. Future Cardiol. 2016 May;12(3):261-8. doi: 10.2217/fca-2015-0009. Epub 2016 Apr 12. PubMed PMID: 27070379.

18: Hassan A, Tajuddin N, Shaikh A. Retrospective Case Series of Patients with Diabetes or Prediabetes Who Were Switched from Omega-3-Acid Ethyl Esters to Icosapent Ethyl. Cardiol Ther. 2015 Jun;4(1):83-93. doi: 10.1007/s40119-014-0032-9. Epub 2014 Dec 17. PubMed PMID: 25515964; PubMed Central PMCID: PMC4472650.

19: Braeckman RA, Stirtan WG, Soni PN. Effect of icosapent ethyl (eicosapentaenoic acid ethyl ester) on omeprazole plasma pharmacokinetics in healthy adults. Drugs R D. 2014 Sep;14(3):159-64. doi: 10.1007/s40268-014-0053-9. PubMed PMID: 24973042; PubMed Central PMCID: PMC4153963.

20: Braeckman RA, Stirtan WG, Soni PN. Pharmacokinetics of Eicosapentaenoic Acid in Plasma and Red Blood Cells After Multiple Oral Dosing With Icosapent Ethyl in Healthy Subjects. Clin Pharmacol Drug Dev. 2014 Mar;3(2):101-108. Epub 2013 Oct 22. PubMed PMID: 26097787; PubMed Central PMCID: PMC4467252.

化学结构

24045 - Icosapent ethyl | CAS 86227-47-6

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