Idasanutlin (RG7388)
编号: 16070812
Cas号: 1229705-06-9
纯度: 98% by HPLC
Idasanutlin; also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist with potential anticancer activity. RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Idasanutlin (RG7388) |
|---|---|
| Iupac 化学名称 | 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid. |
| 同义词 | RG7388; RG 7388 |
| 英文同义词 | RG7388; RG 7388 |
| 分子式 | C31H29Cl2F2N3O4 |
| 分子量 | 616.48247 |
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| InChi | |
| Cas号 | 1229705-06-9 |
| 相关CAS号 |
订购信息
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