JNJ-42165279
编号: 16123025
Cas号: 1346528-50-4
纯度: 98%
JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoylethanolamide (OEA), and palmitoyl ethanolamide (PEA). JNJ-42165279 was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. JNJ-42165279 is currently under clinical trials.
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化学信息
| 名称 | JNJ-42165279 |
|---|---|
| Iupac 化学名称 | N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide |
| 同义词 | JNJ 42165279; JNJ42165279 |
| 英文同义词 | JNJ 42165279; JNJ42165279 |
| 分子式 | C18H17ClF2N4O3 |
| 分子量 | 410.81 |
| Smile | ClC1=C(C=NC=C1)NC(=O)N1CCN(CC1)CC1=CC2=C(OC(O2)(F)F)C=C1 |
| InChiKey | YWGYNGCRVZLMCS-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26) |
| Cas号 | 1346528-50-4 |
| 相关CAS号 |
订购信息
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