JNJ-632
JNJ-632 is a potent HVV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D. Administration of JNJ-632 in HBV genotype D infected chimeric mice, resulted in a 2.77 log reduction of the HBV DNA viral load.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | JNJ-632 |
|---|---|
| Iupac 化学名称 | (S)-N-(4-fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide |
| 同义词 | JNJ-632; JNJ 632; JNJ632. |
| 英文同义词 | JNJ-632; JNJ 632; JNJ632. |
| 分子式 | C18H19FN2O4S |
| 分子量 | 378.4184 |
| Smile | O=C(NC1=CC=C(F)C(C)=C1)C2=CC=CC(S(=O)(N[C@@H]3COCC3)=O)=C2 |
| InChiKey | JIZGLOVJKCSHTH-HNNXBMFYSA-N |
| InChi | InChI=1S/C18H19FN2O4S/c1-12-9-14(5-6-17(12)19)20-18(22)13-3-2-4-16(10-13)26(23,24)21-15-7-8-25-11-15/h2-6,9-10,15,21H,7-8,11H2,1H3,(H,20,22)/t15-/m0/s1 |
| Cas号 | 1572510-42-9 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Vandyck K, Rombouts G, Stoops B, Tahri A, Vos A, Verschueren W, Wu Y, Yang J,
Hou F, Huang B, Vergauwen K, Dehertogh P, Berke JM, Raboisson PJMB. Synthesis and
Evaluation of N-phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly
Modulators inhibiting Hepatitis B Virus (HBV). J Med Chem. 2018 Jun 15. doi:
10.1021/acs.jmedchem.8b00654. [Epub ahead of print] PubMed PMID: 29906396.
2: Berke JM, Dehertogh P, Vergauwen K, Van Damme E, Mostmans W, Vandyck K,
Pauwels F. Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary
Human Hepatocytes Infected with Hepatitis B Virus. Antimicrob Agents Chemother.
2017 Jul 25;61(8). pii: e00560-17. doi: 10.1128/AAC.00560-17. Print 2017 Aug.
PubMed PMID: 28584155; PubMed Central PMCID: PMC5527576.
