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JNJ-63576253

编号: 21250
Cas号: 2110426-27-0
纯度: 98% Min.

TRC253, also known as JNJ63576253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.

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化学信息

名称JNJ-63576253
Iupac 化学名称5-(8-Oxo-5-(6-(piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)-picolinonitrile
同义词TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253;
英文同义词TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253;
分子式 C23H21F3N6O2S
分子量502.5162
SmileN#CC1=NC=C(N(C2=O)C(N(C3=CC=C(OC4CCNCC4)N=C3)C52CCC5)=S)C=C1C(F)(F)F
InChiKeyOUEHJEYKNYQVRC-UHFFFAOYSA-N
InChiInChI=1S/C23H21F3N6O2S/c24-23(25,26)17-10-15(13-29-18(17)11-27)31-20(33)22(6-1-7-22)32(21(31)35)14-2-3-19(30-12-14)34-16-4-8-28-9-5-16/h2-3,10,12-13,16,28H,1,4-9H2
Cas号2110426-27-0
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状Solid powder
纯度98% Min.
存储Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
可溶性Soluble in DMSO
处理方式
运输条件Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

21250 - JNJ-63576253 | CAS 2110426-27-0

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