JQKD82
JQKD82 is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | JQKD82 |
|---|---|
| Iupac 化学名称 | 2,4-diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate |
| 同义词 | JQKD82; JQKD-82; JQKD 82; |
| 英文同义词 | JQKD82; JQKD-82; JQKD 82; |
| 分子式 | C27H40N4O5 |
| 分子量 | 500.63 |
| Smile | O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OC2=CC=C(OC(C)C)C=C2OC(C)C |
| InChiKey | APYABXFXNNTCQD-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H40N4O5/c1-8-31(14-13-30(6)7)26(32)18-28-17-22-15-21(11-12-29-22)27(33)36-24-10-9-23(34-19(2)3)16-25(24)35-20(4)5/h9-12,15-16,19-20,28H,8,13-14,17-18H2,1-7H3 |
| Cas号 | 2410512-38-6 |
| 相关CAS号 | 2,4-diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma Hiroto Ohguchi1*#, Paul M.C. Park2*, Tingjian Wang2*, Berkley E. Gryder3,4*, Daisuke Ogiya5, Keiji Kurata5, Xiaofeng Zhang2, Deyao Li2, Chengkui Pei2, Takeshi Masuda6, Catrine Johansson7, Virangika K. Wimalasena2, Yong Kim3, Shinjiro Hino8, Shingo Usuki9, Yawara Kawano10, Mehmet K. Samur5, Yu-Tzu Tai5, Nikhil C. Munshi5, Masao Matsuoka10, Sumio Ohtsuki6, Mitsuyoshi Nakao8, Takashi Minami11, Shannon Lauberth12, Javed Khan3, Udo Oppermann7,13, Adam D. Durbin14, Kenneth C. Anderson5,15#, Teru Hideshima5#, Jun Qi2,15,16#
