JWH 133 is a potent CB2 selective agonist with Ki of 3.4 nM, 200-fold selective over CB1 receptors.
JWH-133 inhibits IL-12p40 production and enhances IL-10 release by activated macrophages through a CB2 receptor-mediated pathway. a widely used experimental in vitro model to study mechanisms of toxicity and protection in nigral dopaminergic neurons. JWH-133 (10-40 M) induced a concentration-dependent decrease of SH-SY5Y cell viability and proliferation rate.
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名称 | JWH-133 |
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Iupac 化学名称 | JWH-133 |
同义词 | JWH133; JWH 133 |
英文同义词 | JWH133; JWH 133 |
分子式 | C22H32O |
分子量 | 312.49 |
Smile | CCCC(C)(C)c1ccc2c(c1)OC([C@H]3[C@H]2CC(=CC3)C)(C)C |
InChiKey | YSBFLLZNALVODA-RBUKOAKNSA-N |
InChi | InChI=1S/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1 |
Cas号 | 259869-55-1 |
MDL | MFCD06795847 |
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