KU 57788
编号: 160926003
Cas号: 503468-95-9
纯度: 98% by HPLC
Potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin andetoposidein vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | KU 57788 |
|---|---|
| Iupac 化学名称 | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| 同义词 | NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. |
| 英文同义词 | NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. |
| 分子式 | C25H19NO3S |
| 分子量 | 413.49 |
| Smile | C1=CC=C(C=2SC3=C(C21)C=CC=C3)C3=CC=CC=2C(C=C(OC23)N2CCOCC2)=O |
| InChiKey | JAMULYFATHSZJM-UHFFFAOYSA-N |
| InChi | InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2 |
| Cas号 | 503468-95-9 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
