L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ), which specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
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化学信息
名称 | L189 |
Iupac 化学名称 | (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one |
同义词 | L189; L 189; L-189 |
英文同义词 | L189; L 189; L-189 |
分子式 | C11H10N4OS |
分子量 | 246.29 |
Smile | NC1=C(C(NC(N1)=S)=O)/N=C/C1=CC=CC=C1 |
InChiKey | SAKOXVNKDMWWLF-AWNIVKPZSA-N |
InChi | InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)/b13-6+ |
Cas号 | 64232-83-3 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |