LDN-57444 is a Uch-L1 inhibitor with Ki= 0.4 M. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is an intracellular protein abundantly expressed in neurons, and a mutation in UCH-L1 has been identified in familial Parkinson's disease.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | LDN-57444 |
Iupac 化学名称 | (Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one |
同义词 | LDN 57444; LDN57444; UCH-L1 Inhibitor |
英文同义词 | LDN 57444; LDN57444; UCH-L1 Inhibitor |
分子式 | C17H11Cl3N2O3 |
分子量 | 397.64 |
Smile | O=C1N(CC2=CC(Cl)=CC=C2Cl)C3=C(C=C(Cl)C=C3)/C1=N/OC(C)=O |
InChiKey | OPQRFPHLZZPCCH-PGMHBOJBSA-N |
InChi | InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16- |
Cas号 | 668467-91-2 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
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Mechanism | |
Cell study | |
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