Lerociclib HCl (G1T38 HCl)
编号: 2073106
Cas号: 2097938-59-3
纯度: ≧98.0%
Lerociclib HCl (G1T38 dihydrochloride)是一种分化型口服CDK4 / 6抑制剂，对CDK4 / CyclinD1和CDK6 / CyclinD3的IC50分别为1 nM，2 nM。 Lerociclib HCl (G1T38 dihydrochloride)可以在某些类型的乳腺癌和肺癌中与其他靶向疗法联合使用。
Lerociclib (Free base) , 现货库存, Email联系报价。
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Lerociclib HCl (G1T38 HCl) |
|---|---|
| Iupac 化学名称 | 2'-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one dihydrochloride |
| 同义词 | Lerociclib HCl ; G1T38 dihydrochloride ; G1T 38 dihydrochloride |
| 英文同义词 | Lerociclib HCl ; G1T38 dihydrochloride ; G1T 38 dihydrochloride |
| 分子式 | C26H36Cl2N8O |
| 分子量 | 547.52 |
| Smile | O=C1NCC2(N3C1=CC4=CN=C(NC5=NC=C(N6CCN(C(C)C)CC6)C=C5)N=C43)CCCCC2.[H]Cl.[H]Cl |
| InChiKey | IUIVDLVJNPANBY-UHFFFAOYSA-N |
| InChi | InChI=1S/C26H34N8O.2ClH/c1-18(2)32-10-12-33(13-11-32)20-6-7-22(27-16-20)30-25-28-15-19-14-21-24(35)29-17-26(8-4-3-5-9-26)34(21)23(19)31-25;;/h6-7,14-16,18H,3-5,8-13,17H2,1-2H3,(H,29,35)(H,27,28,30,31);2*1H |
| Cas号 | 2097938-59-3 |
| 相关CAS号 | 2097938-59-3 (HCl) ；1628256-23-4 (free base) |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色至浅黄色固体 |
|---|---|
| 纯度 | ≧98.0% |
| 存储 | 短期可在0-4度保存，数天至数月；长期可在-20度保存三年。 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| 运输条件 | 可在常温下运输 |
| 海关编码 | 2933999701 |
Coming soon.
| Targets | CDK4/6 inhibitor |
|---|---|
| Mechanism | Lerociclib (G1T38 ) is a novel, selective,differentiated oral CDK4/6 inhibitor with biochemical IC50 values of 1 nM, 2 nM and 28 μnM for CDK4, CDK6 and CDK9 respectively. Lerociclib (G1T38) with potential use in combination with other targeted therapies in certain types of breast and lung cancer. |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
