Lonafarnib
编号: 16071008
Cas号: 193275-84-2
纯度: 98% by HPLC
Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. Check for active clinical trials or closed clinical trials using this agent.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Lonafarnib |
|---|---|
| Iupac 化学名称 | 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxamide |
| 同义词 | US brand name: Sarasar |
| 英文同义词 | US brand name: Sarasar |
| 分子式 | C27H31Br2ClN4O2 |
| 分子量 | 638.82 |
| Smile | ClC=1C=C(C2=C(CCC=3C(=NC=C(C3)Br)C2C2CCN(CC2)C(CC2CCN(CC2)C(=O)N)=O)C1)Br |
| InChiKey | DHMTURDWPRKSOA-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36) |
| Cas号 | 193275-84-2 |
| 相关CAS号 |
订购信息
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