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Lunresertib

编号: 24080
Cas号: 2719793-90-3
纯度: 98% Min.

Lunresertib, alsop known as RP-6306, is a potent and selective PKMYT1 inhibitor (IC50 = 3.1 nM).

仅供研究使用。 我们不向患者出售。

化学信息

名称Lunresertib
Iupac 化学名称2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
同义词RP-6306; (Rac)-RP-6306; RP 6306; RP6306; lunresertib
英文同义词RP-6306; (Rac)-RP-6306; RP 6306; RP6306; lunresertib
分子式C18H20N4O2
分子量324.38
SmileO=C(C1=C(N)N(C2=C(C)C(O)=CC=C2C)C3=C1C=C(C)C(C)=N3)N
InChiKeyARBRHWRTXPWZGN-UHFFFAOYSA-N
InChiInChI=1S/C18H20N4O2/c1-8-5-6-13(23)10(3)15(8)22-16(19)14(17(20)24)12-7-9(2)11(4)21-18(12)22/h5-7,23H,19H2,1-4H3,(H2,20,24)
Cas号2719793-90-3
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
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外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Szychowski J, Papp R, Dietrich E, Liu B, Vallée F, Leclaire ME, Fourtounis J,
Martino G, Perryman AL, Pau V, Yin SY, Mader P, Roulston A, Truchon JF, Marshall
CG, Diallo M, Duffy NM, Stocco R, Godbout C, Bonneau-Fortin A, Kryczka R,
Bhaskaran V, Mao D, Orlicky S, Beaulieu P, Turcotte P, Kurinov I, Sicheri F,
Mamane Y, Gallant M, Black WC. Discovery of an Orally Bioavailable and Selective
PKMYT1 Inhibitor, RP-6306. J Med Chem. 2022 Aug 11;65(15):10251-10284. doi:
10.1021/acs.jmedchem.2c00552. Epub 2022 Jul 26. PMID: 35880755; PMCID:
PMC9837800.

2: Gallo D, Young JTF, Fourtounis J, Martino G, Álvarez-Quilón A, Bernier C,
Duffy NM, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah
PS, Fortin AB, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S,
Fugère-Desjardins C, Goullet de Rugy T, Leclaire ME, Liu B, Bhaskaran V, Mamane
Y, Melo H, Nicolas O, Singhania A, Szilard RK, Tkáč J, Yin SY, Morris SJ, Zinda
M, Marshall CG, Durocher D. CCNE1 amplification is synthetic lethal with PKMYT1
kinase inhibition. Nature. 2022 Apr;604(7907):749-756. doi:
10.1038/s41586-022-04638-9. Epub 2022 Apr 20. PMID: 35444283; PMCID: PMC9046089.

3: Qi X, Li G, Liu J, Mou L, Zhang Y, Guo S, Chen X, Li W. Structural and
energetic insights into the selective inhibition of PKMYT1 against WEE1. J
Biomol Struct Dyn. 2023 Jun 22:1-9. doi: 10.1080/07391102.2023.2225106. Epub
ahead of print. PMID: 37345529.

化学结构

24080 - Lunresertib | CAS 2719793-90-3

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