Lys05 is a potent lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | Lys05 |
Iupac 化学名称 | Lys05 |
同义词 | Lys-05; Lys 05 |
英文同义词 | Lys-05; Lys 05 |
分子式 | C23H23Cl2N5 |
分子量 | 440.372 |
InChiKey | |
InChi | |
Cas号 | 1391426-22-4 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |