MCC950 sodium
编号: 6111014
Cas号: 256373-96-3
纯度: 98%
MCC950 (CP 456773) sodium is a potent, selective, small molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations.MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1 (IL-1) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | MCC950 sodium |
|---|---|
| Iupac 化学名称 | sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide |
| 同义词 | MCC950 , CP-456773 |
| 英文同义词 | MCC950 , CP-456773 |
| 分子式 | C20H23N2NaO5S |
| 分子量 | 426.46 |
| Smile | O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+] |
| InChiKey | LFQQNXFKPNZRFT-UHFFFAOYSA-M |
| InChi | InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1 |
| Cas号 | 256373-96-3 |
| 相关CAS号 | 256373-96-3 (sodium) 210826-40-7 (free acid) |
订购信息
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