MDK-7553
MDK-7553, also known as CD38 inhibitor 78c and Compound-78c, is a potent CD38 inhibitor. MDK-7553 has CAS#1700637-55-3, which was reported in J Med Chem. 2015 Apr 23;58(8):3548-71. For the convenience of scientific communication, we name it as MDK-7553. The last four digits of CAS# were used for its name.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | MDK-7553 |
|---|---|
| Iupac 化学名称 | 4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one |
| 同义词 | CD38 inhibitor 78c; Compound-78c; CD38i_78c; 78c; Cluster of Differentiation 38 Inhibitor; MDK-7553; MDK 7553; MDK7553; CD38-IN-78c; CD38 IN-78c; CD38IN-78c: CD38 inhibitor 78c; |
| 英文同义词 | CD38 inhibitor 78c; Compound-78c; CD38i_78c; 78c; Cluster of Differentiation 38 Inhibitor; MDK-7553; MDK 7553; MDK7553; CD38-IN-78c; CD38 IN-78c; CD38IN-78c: CD38 inhibitor 78c; |
| 分子式 | C22H27N3O3S |
| 分子量 | 413.53 |
| Smile | O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1 |
| InChiKey | VJQALSOBHVEJQM-QAQDUYKDSA-N |
| InChi | InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17- |
| Cas号 | 1700637-55-3 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, Jeune
MR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG,
Shearer TW, Shewchuk LM, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC.
Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors
of NAD-Hydrolyzing Enzyme CD38. J Med Chem. 2015 Sep 10;58(17):7021-56. doi:
10.1021/acs.jmedchem.5b00992. Epub 2015 Aug 24. PubMed PMID: 26267483.
2: Tarragó MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud
M, Samani A, Hein KZ, Huang R, Jurk D, Cho DS, Boslett JJ, Miller JD, Zweier JL,
Passos JF, Doles JD, Becherer DJ, Chini EN. A Potent and Specific CD38 Inhibitor
Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD(+) Decline.
Cell Metab. 2018 May 1;27(5):1081-1095.e10. doi: 10.1016/j.cmet.2018.03.016.
PubMed PMID: 29719225; PubMed Central PMCID: PMC5935140.
