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MIF098

编号: 24150
Cas号: 1208448-95-6
纯度: 98% Min.

MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.


仅供研究使用。 我们不向患者出售。

化学信息

名称MIF098
Iupac 化学名称3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one
同义词MIF098; MIF-098; MIF 098
英文同义词MIF098; MIF-098; MIF 098
分子式C15H13NO3
分子量255.27
SmileO=C1OC2=CC=C(C)C=C2N1CC3=CC=CC(O)=C3
InChiKeyJJXKGUBHEQGADG-UHFFFAOYSA-N
InChiInChI=1S/C15H13NO3/c1-10-5-6-14-13(7-10)16(15(18)19-14)9-11-3-2-4-12(17)8-11/h2-8,17H,9H2,1H3
Cas号1208448-95-6
相关CAS号

订购信息

包装价格库存纯度备货期
大货询价询价询价
Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Huang H, Chen D, Pu J, Yuan A, Fu Q, Li J, Leng L, Bucala R, Ye S, Lu L. The
small molecule macrophage migration inhibitory factor antagonist MIF098,
inhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol.
2019 Nov;76:105874. doi: 10.1016/j.intimp.2019.105874. Epub 2019 Sep 6. PMID:
31499270.

2: Harrison DE, Strong R, Reifsnyder P, Kumar N, Fernandez E, Flurkey K, Javors
MA, Lopez-Cruzan M, Macchiarini F, Nelson JF, Markewych A, Bitto A, Sindler AL,
Cortopassi G, Kavanagh K, Leng L, Bucala R, Rosenthal N, Salmon A, Stearns TM,
Bogue M, Miller RA. 17-a-estradiol late in life extends lifespan in aging UM-
HET3 male mice; nicotinamide riboside and three other drugs do not affect
lifespan in either sex. Aging Cell. 2021 May;20(5):e13328. doi:
10.1111/acel.13328. Epub 2021 Mar 31. Erratum in: Aging Cell. 2022
Nov;21(11):e13672. doi: 10.1111/acel.13672. PMID: 33788371; PMCID: PMC8135004.

3: Shin MS, Kang Y, Wahl ER, Park HJ, Lazova R, Leng L, Mamula M, Krishnaswamy
S, Bucala R, Kang I. Macrophage Migration Inhibitory Factor Regulates U1 Small
Nuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome.
Arthritis Rheumatol. 2019 Jan;71(1):109-120. doi: 10.1002/art.40672. Epub 2018
Dec 4. PMID: 30009530; PMCID: PMC6310104.

4: Poulsen KL, McMullen MR, Huang E, Kibler CD, Sheehan MM, Leng L, Bucala R,
Nagy LE. Novel Role of Macrophage Migration Inhibitory Factor in Upstream
Control of the Unfolded Protein Response After Ethanol Feeding in Mice. Alcohol
Clin Exp Res. 2019 Jul;43(7):1439-1451. doi: 10.1111/acer.14065. Epub 2019 May
14. PMID: 31009094; PMCID: PMC6602811.

5: Ma F, Hunt DE, Leng L, Bucala R, Meyer-Siegler KL, Vera PL. Protease
activated-receptor 4 activation as a model of persistent bladder pain: Essential
role of macrophage migration inhibitory factor and high mobility group box 1.
Int J Urol. 2018 Oct;25(10):887-893. doi: 10.1111/iju.13778. Epub 2018 Aug 15.
PMID: 30112848; PMCID: PMC6436093.

化学结构

24150 - MIF098 | CAS 1208448-95-6

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