ML323 is a highly potent and selective USP1-UAF1 inhibitor with IC50 of 76 nM.ML323 inhibits the deubiquitination of PCNA and FANCD2 by inhibiting USP1CUAF1 activity in H596 cells. Moreover, ML323 potentiates cisplatin cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting two major DNA damage response pathways (TLS and FA).
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化学信息
名称 | ML323 |
Iupac 化学名称 | ML323 |
同义词 | N/A |
英文同义词 | N/A |
分子式 | C23H24N6 |
分子量 | 384.48 |
InChiKey | |
InChi | |
Cas号 | 1572414-83-5 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |