ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.
ML346 has good chemical stability, significantly high water solubility, is not reactive with excess glutathione, and is cell permeable. The probe ML346 will help elucidate roles for activation of Hsp70 and HSF-1 in the prevention and progression of cancers, cellular aging, and metabolic and neurodegenerative disorders. ML346 is a novel modulator of proteostasis for protein conformational diseases.
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名称 | ML346 |
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Iupac 化学名称 | ML346 |
同义词 | ML-346 |
英文同义词 | ML-346 |
分子式 | C14H12N2O4 |
分子量 | 272.26 |
InChiKey | |
InChi | |
Cas号 | 100872-83-1 |
相关CAS号 |
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