ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia.ML390 was active with an ED50 (effective concentration triggering 50% of its maximal differentiation activity) of 2 M in murine and human AML cell lines, offering insight into the mechanism of overcoming differentiation arrest. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia
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化学信息
名称 | ML390 |
Iupac 化学名称 | ML390 |
同义词 | N/A |
英文同义词 | N/A |
分子式 | C21H21F3N2O3 |
分子量 | 406.4 |
Smile | C[Si](C)(C)CSCCl |
InChiKey | IKWIERSJEROYFH-UHFFFAOYSA-N |
InChi | InChI=1S/C5H13ClSSi/c1-8(2,3)5-7-4-6/h4-5H2,1-3H3 |
Cas号 | 2029049-79-2 |
MDL | MFCD17013410 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |