MVN38807
MVN38807, also known as Y-1, is neuraminidase (NA) inhibitor used in preparation of drugs for resisting H1N1 influenza virus. Y-1 exerts the best inhibition activity (IC50 = 0.21 μM) against NA, which is better than oseltamivir carboxylate (OSC) (IC50 = 3.04 μM) and lead AN-329/10738021 (IC50 = 1.92 μM). This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digits of its CAS number (see MedKoo Chemical Nomenclature, https://www.medkoo.com/page/naming).
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | MVN38807 |
|---|---|
| Iupac 化学名称 | Benzoic acid, 3,5-dihydroxy-, (2E)-2-[(4-hydroxy-3-nitrophenyl)methylene]hydrazide |
| 同义词 | Y-1; Y1; Y 1; MVN38807; MVN-38807; MVN 38807; |
| 英文同义词 | Y-1; Y1; Y 1; MVN38807; MVN-38807; MVN 38807; |
| 分子式 | C14H11N3O6 |
| 分子量 | 317.257 |
| Smile | O=C(N/N=C/C1=CC=C(O)C([N+]([O-])=O)=C1)C2=CC(O)=CC(O)=C2 |
| InChiKey | MCGROFKAAXXTBN-VIZOYTHASA-N |
| InChi | InChI=1S/C14H11N3O6/c18-10-4-9(5-11(19)6-10)14(21)16-15-7-8-1-2-13(20)12(3-8)17(22)23/h1-7,18-20H,(H,16,21)/b15-7+ |
| Cas号 | 2379438-80-7 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 可溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Yu R, Cheng LP, Li M, Pang W. Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay. ACS Med Chem Lett. 2019 Nov 25;10(12):1667-1673. doi: 10.1021/acsmedchemlett.9b00447. PMID: 31857844; PMCID: PMC6912870.
