Mobocertinib, also known as TAK-788 and AP32788, is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions. TAK-788 exhibits antitumor activity in pts with EGFR exon 20 insertions with an AE profile consistent with other EGFR TKIs.
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名称 | Mobocertinib free base |
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Iupac 化学名称 | propan-2-yl 2-[4-{[2-(dimethylamino)ethyl](methyl)amino}-2-methoxy-5-(prop-2-enamido)anilino]-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate |
同义词 | Mobocertinib; TAK-788; TAK 788; TAK788; AP32788; AP-32788; AP 32788;Mobocertinib free base |
英文同义词 | Mobocertinib; TAK-788; TAK 788; TAK788; AP32788; AP-32788; AP 32788;Mobocertinib free base |
分子式 | C32H39N7O4 |
分子量 | 585.71 |
Smile | O=C(C1=CN=C(NC2=CC(NC(C=C)=O)=C(N(CCN(C)C)C)C=C2OC)N=C1C3=CN(C)C4=C3C=CC=C4)OC(C)C |
InChiKey | AZSRSNUQCUDCGG-UHFFFAOYSA-N |
InChi | InChI=1S/C32H39N7O4/c1-9-29(40)34-24-16-25(28(42-8)17-27(24)38(6)15-14-37(4)5)35-32-33-18-22(31(41)43-20(2)3)30(36-32)23-19-39(7)26-13-11-10-12-21(23)26/h9-13,16-20H,1,14-15H2,2-8H3,(H,34,40)(H,33,35,36) |
Cas号 | 1847461-43-1 |
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