NCC007
编号: 2071529
Cas号:
纯度: 98% Min.
NCC007 is a novel CKIα and CKIδ dual inhibitor. NCC007 that showed stronger period effects (0.32 μM for 5 h period lengthening) in a cellbased circadian assay. The following in vitro kinase assay showed that NCC007 inhibited CKIα and CKIδ with an IC50 of 1.8 and 3.6 μM. We further demonstrated that NCC007 lengthened the period of mouse behavioral rhythms in vivo. Thus, NCC007 is a valuable tool compound to control circadian rhythms through CKI inhibition.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | NCC007 |
|---|---|
| Iupac 化学名称 | 9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine |
| 同义词 | NCC007; NCC-007; NCC 007; |
| 英文同义词 | NCC007; NCC-007; NCC 007; |
| 分子式 | C22H28F3N7 |
| 分子量 | 447.5102 |
| Smile | FC(C1=CC(CNC2=C3N=CN(C(C4CC4)C)C3=NC(NCCN(C)C)=N2)=CC=C1)(F)F |
| InChiKey | GHRNSZVMIARHIS-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H28F3N7/c1-14(16-7-8-16)32-13-28-18-19(29-21(30-20(18)32)26-9-10-31(2)3)27-12-15-5-4-6-17(11-15)22(23,24)25/h4-6,11,13-14,16H,7-10,12H2,1-3H3,(H2,26,27,29,30) |
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