NT219 is a novel inhibitor of the insulin/igf signaling cascade (iis), mediating a long-lasting, highly efficient inhibition by a dual mechanism: it reduces the autophosphorylation of the igf1 receptor and directs the insulin receptor substrates 1 and 2 (irs 1/2) for degradation
仅供研究使用。 我们不向患者出售。
名称 | NT219 |
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Iupac 化学名称 | (E)-3-(2-Bromo-3,4-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide |
同义词 | NT219; NT 219; NT-219 |
英文同义词 | NT219; NT 219; NT-219 |
分子式 | C16H14BrNO5S |
分子量 | 412.26 |
Smile | S=C(NCC1=CC(O)=C(O)C(O)=C1)/C=C/C2=CC=C(O)C(O)=C2Br |
InChiKey | XDDQKKXXQHUUHJ-DUXPYHPUSA-N |
InChi | InChI=1S/C16H14BrNO5S/c17-14-9(1-3-10(19)16(14)23)2-4-13(24)18-7-8-5-11(20)15(22)12(21)6-8/h1-6,19-23H,7H2,(H,18,24)/b4-2+ |
Cas号 | 1198078-60-2 |
相关CAS号 |
包装 | 价格 | 库存 | 纯度 | 备货期 |
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大货 | 询价 | 询价 | 询价 |
外观性状 | 类白色固体 |
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纯度 | 98% Min. |
存储 | 0-4℃,可保存几天到几周;-20℃,可保存 几个月。 |
可溶性 | 溶于DMSO等有机溶剂 |
处理方式 | |
运输条件 | 可以在室温下进行运输。 |
海关编码 |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |
1: Moll L, Ben-Gedalya T, Reuveni H, Cohen E. The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition. FASEB J. 2016 Apr;30(4):1656-69. doi: 10.1096/fj.15-281675. Epub 2015 Dec 31. PubMed PMID: 26722006.
2: El-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell. 2014 Feb;13(1):165-74. doi: 10.1111/acel.12171. Epub 2013 Nov 22. PubMed PMID: 24261972; PubMed Central PMCID: PMC4326862.