NU 7026
编号: 6118017
Cas号: 154447-35-5
纯度: 98%
NU 7026 is a novel and potential inhibitor of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK) with IC50 of 0.23 uM; displays selectivity over other PIKK family enzymes.
NU7026 treatment resulted in significant reduction in the number of H2AX foci after -irradiation in wild-type cells, but had no significant effect in RIC1 cells .NU7026 underwent rapid plasma clearance (0.108 l h(-1)) and this was largely attributed to extensive metabolism. Bioavailability following interperitoneal (i.p.) and p.o. administration at 20 mg kg(-1) was 20 and 15%, respectively .
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | NU 7026 |
|---|---|
| Iupac 化学名称 | NU 7026 |
| 同义词 | LY293646; NU7026; NU-7026; LY 293646; LY-293646 |
| 英文同义词 | LY293646; NU7026; NU-7026; LY 293646; LY-293646 |
| 分子式 | C17H15NO3 |
| 分子量 | 281.31 |
| Smile | c1ccc2c(c1)ccc3c2oc(cc3=O)N4CCOCC4 |
| InChiKey | KKTZALUTXUZPSN-UHFFFAOYSA-N |
| InChi | InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2 |
| Cas号 | 154447-35-5 |
| MDL | MFCD06798345 |
| 相关CAS号 |
订购信息
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