Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2C3 days. The metabolites are excreted in the urine and feces.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | Naftifine |
Iupac 化学名称 | Naftifine |
同义词 | AW 105843; AW105843; AW-105843; AW 105-843; SN 105843; SN105843; SN-105843; Naftifine, Naftifine hydrochloride; Naftin |
英文同义词 | AW 105843; AW105843; AW-105843; AW 105-843; SN 105843; SN105843; SN-105843; Naftifine, Naftifine hydrochloride; Naftin |
分子式 | C21H22ClN |
分子量 | 323.864 |
Smile | CN(C/C=C/c1ccccc1)Cc2cccc3c2cccc3.Cl |
InChiKey | OLUNPKFOFGZHRT-YGCVIUNWSA-N |
InChi | InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+; |
Cas号 | 65472-88-0 |
MDL | MFCD00059047 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |