Nastorazepide
Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Z-360 binds to the gastrin/CCK-2 receptor, thereby preventing receptor activation by gastrin, a peptide hormone frequently associated with the proliferation of gastrointestinal and pancreatic tumor cells. Check for active clinical trials or closed clinical trials using this agent. Z-360 is a novel orally active CCK-2/gastrin receptor antagonist, significantly inhibits the growth of subcutaneous xenografts of human pancreatic tumor cells in mice, and that Z-360 combined with gemcitabine prolonged survival in a pancreatic carcinoma orthotopic xenograft mice.
Nastorazepide (Z-360), Bulk in stock, contact us by email for Bulk quotation.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Nastorazepide |
|---|---|
| Iupac 化学名称 | (R)-3-(3-(5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)ureido)benzoic acid |
| 同义词 | Z-360 ; Z360 ; Z 360 |
| 英文同义词 | Z-360 ; Z360 ; Z 360 |
| 分子式 | C29H36N4O5 |
| 分子量 | 520.62 |
| Smile | O=C(O)C1=CC=CC(NC(N[C@@H]2CN(C3CCCCC3)C4=CC=CC=C4N(CC(C(C)(C)C)=O)C2=O)=O)=C1 |
| InChiKey | VIJCCFFEBCOOIE-JOCHJYFZSA-N |
| InChi | InChI=1S/C29H36N4O5/c1-29(2,3)25(34)18-33-24-15-8-7-14-23(24)32(21-12-5-4-6-13-21)17-22(26(33)35)31-28(38)30-20-11-9-10-19(16-20)27(36)37/h7-11,14-16,21-22H,4-6,12-13,17-18H2,1-3H3,(H,36,37)(H2,30,31,38)/t22-/m1/s1 |
| Cas号 | 209219-38-5 |
| 相关CAS号 |
订购信息
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