PF-04979064
编号: 611902
Cas号: 1220699-06-8
纯度: ≧98.0%
PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM. PF-04979064 exhibited excellent in vitro potency, very good solubility, high LipE, excellent kinome selectivity,24 robust PK/PD correlation and TGI efficacy, and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism.
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化学信息
| 名称 | PF-04979064 |
|---|---|
| Iupac 化学名称 | (S)-1-(1-(2-hydroxypropanoyl)piperidin-4-yl)-3-methyl-8-(6-methylpyridin-3-yl)-1H-imidazo[4,5-c][1,5]naphthyridin-2(3H)-one |
| 同义词 | PF-04979064 ; PF 04979064 ; PF04979064 |
| 英文同义词 | PF-04979064 ; PF 04979064 ; PF04979064 |
| 分子式 | C24H26N6O3 |
| 分子量 | 446.5 |
| Smile | O=C(N1C2CCN(C([C@@H](O)C)=O)CC2)N(C)C3=C1C4=NC(C5=CC=C(C)N=C5)=CC=C4N=C3 |
| InChiKey | GACQNUHFDBEIQH-HNNXBMFYSA-N |
| InChi | InChI=1S/C24H26N6O3/c1-14-4-5-16(12-25-14)18-6-7-19-21(27-18)22-20(13-26-19)28(3)24(33)30(22)17-8-10-29(11-9-17)23(32)15(2)31/h4-7,12-13,15,17,31H,8-11H2,1-3H3/t15-/m0/s1 |
| Cas号 | 1220699-06-8 |
| 相关CAS号 | 1220699-06-8 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
