PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
仅供研究使用。 我们不向患者出售。
化学信息
名称 | PLX7904 |
Iupac 化学名称 | PLX7904 |
同义词 | PB04 |
英文同义词 | PB04 |
分子式 | C24H22F2N6O3S |
分子量 | 512.53 |
InChiKey | |
InChi | |
Cas号 | 1393465-84-3 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
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Mechanism | |
Cell study | |
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