Paritaprevir
编号: 16060702
Cas号: 1216941-48-8
纯度: 98% by HPLC
Paritaprevir, also known as ABT-450, is an acylsulfonamide inhibitor of the NS3-4A serine protease manufactured by Abbott Laboratories that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1. Resistance to treatment with paritaprevir is uncommon, because it targets the binding site, but has been seen to arise due to mutations at positions 155 and 168 in NS3
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化学信息
| 名称 | Paritaprevir |
|---|---|
| Iupac 化学名称 | (2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(5-methylpyrazine-2-carboxamido)-5,16-dioxo-2-(phenanthridin-6-yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide |
| 同义词 | ABT-450 |
| 英文同义词 | ABT-450 |
| 分子式 | C40H43N7O7S |
| 分子量 | 765.88 |
| Smile | C1(CC1)S(=O)(=O)NC(=O)[C@]12NC([C@H]3N(C([C@H](CCCCC\C=C/[C@@H]1C2)NC(=O)C2=NC=C(N=C2)C)=O)C[C@@H](C3)OC=3N=C2C=CC=CC2=C2C=CC=CC32)=O |
| InChiKey | UAUIUKWPKRJZJV-QPLHLKROSA-N |
| InChi | InChI=1S/C40H43N7O7S/c1-24-21-42-33(22-41-24)35(48)43-32-16-6-4-2-3-5-11-25-20-40(25,39(51)46-55(52,53)27-17-18-27)45-36(49)34-19-26(23-47(34)38(32)50)54-37-30-14-8-7-12-28(30)29-13-9-10-15-31(29)44-37/h5,7-15,21-22,25-27,32,34H,2-4,6,16-20,23H2,1H3,(H,43,48)(H,45,49)(H,46,51)/b11-5-/t25-,26-,32+,34+,40-/m1/s1 |
| Cas号 | 1216941-48-8 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
