Parsaclisib HCl
编号: L20333
Cas号: 1995889-48-9
纯度: 98% Min.
Parsaclisib, also known as INCB050465, is a novel PI3Kδ inhibitor which synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. INCB050465 inhibits PI3Kδ (IC50 = 1 nM at 1 mM ATP) with approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. INCB050465 demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM. In addition, INCB050465 blocks the proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM) and can slow tumor growth in the Pfeiffer model of DLBCL in vivo.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Parsaclisib HCl |
|---|---|
| Iupac 化学名称 | (4R)-4-{3-[(1S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl}pyrrolidin-2-one hydrochloride |
| 同义词 | INCB50465 HCl; INCB-50465; INCB 50465; INCB050465 HCl; INCB-050465; INCB 050465; INCB050465 free base; Parsaclisib hydrochloride; Parsaclisib HCl; |
| 英文同义词 | INCB50465 HCl; INCB-50465; INCB 50465; INCB050465 HCl; INCB-050465; INCB 050465; INCB050465 free base; Parsaclisib hydrochloride; Parsaclisib HCl; |
| 分子式 | C20H23Cl2FN6O2 |
| 分子量 | 469.34 |
| Smile | O=C1NC[C@@H](C2=C(F)C(Cl)=CC([C@@H](N3N=C(C)C4=C(N)N=CN=C43)C)=C2OCC)C1.[H]Cl |
| InChiKey | TWHUONANZMKBKX-ACMTZBLWSA-N |
| InChi | InChI=1S/C20H22ClFN6O2.ClH/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20;/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26);1H/t10-,11-;/m0./s1 |
| Cas号 | 1995889-48-9 |
| 相关CAS号 |
订购信息
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