Pevonedistat
编号: 16071408
Cas号: 905579-51-3
纯度: 98% by HPLC
Pevonedistat, also known as MLN-4924 and TAK-924, is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP).
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Pevonedistat |
|---|---|
| Iupac 化学名称 | ((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate |
| 同义词 | TAK-924; TAK 924; |
| 英文同义词 | TAK-924; TAK 924; |
| 分子式 | C21H25N5O4S |
| 分子量 | 443.52 |
| Smile | S(N)(OC[C@H]1[C@H](C[C@@H](C1)N1C=CC2=C1N=CN=C2N[C@H]2CCC1=CC=CC=C21)O)(=O)=O |
| InChiKey | MPUQHZXIXSTTDU-QXGSTGNESA-N |
| InChi | InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1 |
| Cas号 | 905579-51-3 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
