Piperoxan, also known as benodaine, is a drug which was the very first antihistamine to be discovered. This compound, derived from benzodioxan, was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France. Formerly investigated by Fourneau as an -adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs.
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化学信息
名称 | Piperoxan HCl |
Iupac 化学名称 | 1-((2,3-Dihydro-1,4-benzodioxin-2-yl)methyl)piperidinium chloride |
同义词 | Piperoxan HCl; F 933 hydrochloride; F933; F-933; F 933; Piperoxane hydrochloride; benodaine |
英文同义词 | Piperoxan HCl; F 933 hydrochloride; F933; F-933; F 933; Piperoxane hydrochloride; benodaine |
分子式 | C14H20ClNO2 |
分子量 | 269.769 |
Smile | [Cl-].O1C(COC2=C1C=CC=C2)C[NH+]2CCCCC2 |
InChiKey | BITRJBQGQMGGQI-UHFFFAOYSA-N |
InChi | InChI=1S/C14H19NO2.ClH/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12;/h2-3,6-7,12H,1,4-5,8-11H2;1H |
Cas号 | 135-87-5 |
相关CAS号 | |
外观性状 | off-white solid |
纯度 | 98% |
存储 | 3 years -20ºCpowder |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature as non-hazardous chemical. |
海关编码 | |
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Mechanism | |
Cell study | |
Animal study | |
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