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Pluripotin(SC-1)

编号: 100502
Cas号: 839707-37-8
纯度: 98% by HPLC 

SC1 (Pluripotin) was identified in a cell-based chemical  library screen for small   molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo.  

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化学信息

名称Pluripotin(SC-1)
Iupac 化学名称N-(3-(7-((1,3-dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide 
同义词Pluripotin,SC-1,SC1,SC 1 
英文同义词Pluripotin,SC-1,SC1,SC 1 
分子式C27H25F3N8O2 
分子量550.54621 
SmileO=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC(C)=NN4C)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
InChiKeyNBZFRTJWEIHFPF-UHFFFAOYSA-N
InChiInChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
Cas号839707-37-8
相关CAS号

订购信息

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外观性状crystalline solid 
纯度98% by HPLC 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
可溶性Soluble in DMSO to 20 mM 
处理方式
运输条件Shipped under ambient temperature 
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

100502 - Pluripotin(SC-1) | CAS 839707-37-8

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