SC1 (Pluripotin) was identified in a cell-based chemical library screen for small molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo.
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化学信息
名称 | Pluripotin(SC-1) |
Iupac 化学名称 | N-(3-(7-((1,3-dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide |
同义词 | Pluripotin,SC-1,SC1,SC 1 |
英文同义词 | Pluripotin,SC-1,SC1,SC 1 |
分子式 | C27H25F3N8O2 |
分子量 | 550.54621 |
Smile | O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC(C)=NN4C)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5 |
InChiKey | NBZFRTJWEIHFPF-UHFFFAOYSA-N |
InChi | InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34) |
Cas号 | 839707-37-8 |
相关CAS号 | |
外观性状 | crystalline solid |
纯度 | 98% by HPLC |
存储 | 3 years -20ºCpowder 6 months-80ºCin solvent |
可溶性 | Soluble in DMSO to 20 mM |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |