RO31-8220 mesylate
编号: 16060303
Cas号: 138489-18-6
纯度: 98% by HPLC
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%. Ro-31-8220 showed the apoptotic effect on HL-60 cells, which was mediated by a well-characterized transduction process of apoptotic signals: i.e., mitochondrial cytochrome c efflux and the activation of caspase-3 in the cytosol. Moreover, the ability of Ro-31-8220 to induce apoptotic activation was completely inhibited by the over-expression of the apoptotic suppressor gene, Bcl-2, in the cells
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化学信息
| 名称 | RO31-8220 mesylate |
|---|---|
| Iupac 化学名称 | 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate methanesulfonate |
| 同义词 | RO-318220; RO 318220 |
| 英文同义词 | RO-318220; RO 318220 |
| 分子式 | C26H27N5O5S2 |
| 分子量 | 553.652 |
| Smile | CS(=O)(=O)O.C(N)(=N)SCCCN1C=C(C2=CC=CC=C12)C=1C(NC(C1C1=CN(C2=CC=CC=C12)C)=O)=O |
| InChiKey | SAWVGDJBSPLRRB-UHFFFAOYSA-N |
| InChi | InChI=1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4) |
| Cas号 | 138489-18-6 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
