Relugolix, also known as TAK-385, is a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally. By preventing LH-RH from binding with the LH-RH receptor in the anterior pituitary gland and suppressing the secretion of luteinizing hormone (LH) and follicle stimulation hormone (FSH) from the anterior pituitary gland, TAK-385 controls the effect of LH and FSH on the ovary, reduces the level of estrogen in blood, which is known to be associated with the development of endometriosis and uterine fibroids, and is expected to improve the symptoms of these disorders
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化学信息
名称 | Relugolix |
Iupac 化学名称 | 1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea |
同义词 | Relugolix; TAK385 |
英文同义词 | Relugolix; TAK385 |
分子式 | C29H27F2N7O5S |
分子量 | 623.63 |
Smile | FC1=C(CN2C(N(C(C3=C2SC(=C3CN(C)C)C3=CC=C(C=C3)NC(=O)NOC)=O)C=3N=NC(=CC3)OC)=O)C(=CC=C1)F |
InChiKey | AOMXMOCNKJTRQP-UHFFFAOYSA-N |
InChi | InChI=1S/C29H27F2N7O5S/c1-36(2)14-19-24-26(39)38(22-12-13-23(42-3)34-33-22)29(41)37(15-18-20(30)6-5-7-21(18)31)27(24)44-25(19)16-8-10-17(11-9-16)32-28(40)35-43-4/h5-13H,14-15H2,1-4H3,(H2,32,35,40) |
Cas号 | 737789-87-6 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% by HPLC |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
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Mechanism | |
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