Risvodetinib
Risvodetinib, also known as IkT-148009., is a brain-penetrant c-Abl inhibitor with a favorable toxicology profile. IkT-148009 suppressed c-Abl activation to baseline and substantially protected dopaminergic neurons from degeneration when administered therapeutically by once daily oral gavage beginning 4 weeks after disease initiation. Recovery of motor function in PD mice occurred within 8 weeks of initiating treatment concomitantly with a reduction in α-synuclein pathology in the mouse brain. IkT-148009 may have potential as a disease-modifying therapy in PD.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Risvodetinib |
|---|---|
| Iupac 化学名称 | N-[4-methyl-3-({4-[5-(4-methyl-1,2-oxazol-5-yl)pyridin-3-yl]pyrimidin- 2-yl}amino)phenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide |
| 同义词 | Risvodetinib; IkT-148009; IkT 148009; IkT148009; |
| 英文同义词 | Risvodetinib; IkT-148009; IkT 148009; IkT148009; |
| 分子式 | C33H34N8O2 |
| 分子量 | 574.68 |
| Smile | O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC(C4=C(C)C=NO4)=CN=C3)=N2)=C1)C5=CC=C(CN6CCN(C)CC6)C=C5 |
| InChiKey | ADGOPPKEIZXKAZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C33H34N8O2/c1-22-4-9-28(37-32(42)25-7-5-24(6-8-25)21-41-14-12-40(3)13-15-41)17-30(22)39-33-35-11-10-29(38-33)26-16-27(20-34-19-26)31-23(2)18-36-43-31/h4-11,16-20H,12-15,21H2,1-3H3,(H,37,42)(H,35,38,39) |
| Cas号 | 2031185-00-7 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Karuppagounder SS, Wang H, Kelly T, Rush R, Nguyen R, Bisen S, Yamashita Y, Sloan N, Dang B, Sigmon A, Lee HW, Marino Lee S, Watkins L, Kim E, Brahmachari S, Kumar M, Werner MH, Dawson TM, Dawson VL. The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease. Sci Transl Med. 2023 Jan 18;15(679):eabp9352. doi: 10.1126/scitranslmed.abp9352. Epub 2023 Jan 18. PMID: 36652533.
