SABA1
SABA1 is an antibacterial agent against Pseudomonas aeruginosa and Escherichia coli. It functions by inhibiting biotin carboxylase (BC), an enzyme that catalyzes the first half-reaction of acetyl-CoA carboxylase (ACC), which is essential for fatty acid synthesis in bacteria. Notably, SABA1 exhibits an atypical inhibition mechanism by binding to the biotin binding site of BC in the presence of ADP. This unique mode of action positions SABA1 as a promising candidate in the development of new antibiotics, especially crucial in the face of rising antimicrobial resistance.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | SABA1 |
|---|---|
| Iupac 化学名称 | ethyl 4-((2-chloro-5-(phenylcarbamoyl)phenyl)sulfonamido)benzoate |
| 同义词 | SABA1; SABA 1; SABA-1 |
| 英文同义词 | SABA1; SABA 1; SABA-1 |
| 分子式 | C22H19ClN2O5S |
| 分子量 | 458.91 |
| Smile | CCOC(C1=CC=C(C=C1)NS(=O)(C2=CC(C(NC3=CC=CC=C3)=O)=CC=C2Cl)=O)=O |
| InChiKey | LCDQWAPYDBBYCH-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H19ClN2O5S/c1-2-30-22(27)15-8-11-18(12-9-15)25-31(28,29)20-14-16(10-13-19(20)23)21(26)24-17-6-4-3-5-7-17/h3-14,25H,2H2,1H3,(H,24,26) |
| Cas号 | 690681-65-3 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色固体 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 0-4℃，可保存几天到几周；-20℃，可保存 几个月。 |
| 可溶性 | 溶于DMSO等有机溶剂 |
| 处理方式 | |
| 运输条件 | 可以在室温下进行运输。 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Craft MK, Waldrop GL. Mechanism of biotin carboxylase inhibition by ethyl
4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulphonylamino]benzoate. J Enzyme Inhib
Med Chem. 2022 Dec;37(1):100-108. doi: 10.1080/14756366.2021.1994558. PMID:
34894987; PMCID: PMC8667948.
2: Kloser A, Laird M, Deng M, Misra R. Modulations in lipid A and phospholipid
biosynthesis pathways influence outer membrane protein assembly in Escherichia
coli K-12. Mol Microbiol. 1998 Mar;27(5):1003-8. doi:
10.1046/j.1365-2958.1998.00746.x. PMID: 9535089.
3: Li Z, Huang L, Chen X, Liu Q, Liu Y, Liu C, Yu C, Feng Y. Contribution of
plant growth-promoting endophytic bacteria from hyperaccumulator to non-host
plant zinc nutrition and health. Int J Phytoremediation. 2025;27(1):23-35. doi:
10.1080/15226514.2024.2395983. Epub 2024 Aug 26. PMID: 39185733.
