SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM).
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化学信息
名称 | SCH900776 |
分子式 | C15H18BrN7 |
分子量 | 376.25 |
Smile | Cn1cc(cn1)c2cnn3c2nc(c(c3N)Br)[C@@H]4CCCNC4 |
InChiKey | GMIZZEXBPRLVIV-SECBINFHSA-N |
InChi | InChI=1S/C15H18BrN7/c1-22-8-10(6-19-22)11-7-20-23-14(17)12(16)13(21-15(11)23)9-3-2-4-18-5-9/h6-9,18H,2-5,17H2,1H3/t9-/m1/s1 |
Cas号 | 891494-63-6 |
MDL | MFCD20922873 |
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