SDU-071
SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 suppresses BRD4 interaction with the p53 tumor suppressor and its biological activity in MDA-MB-231 triple-negative breast cancer (TNBC) cells in vitro and in vivo. SDU-071 suppresses cell proliferation, migration, and invasion by downregulating the expression of BRD4-targeted genes, such as c-Myc and Mucin 5AC, and inducing cell cycle arrest and apoptosis, as demonstrated in cultured MDA-MB-231 TNBC cells. Its antitumor activity is illustrated in an orthotopic mouse xenograft mammary tumor model. SDU-071 is a viable option for potentially treating TNBC as a new BRD4-p53 inhibitor.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | SDU-071 |
|---|---|
| Iupac 化学名称 | N-(4-methoxyphenyl)-2-(((4-methoxyphenyl)amino)methyl)benzo[h]quinolin-4-amine |
| 同义词 | SDU-071; SDU 071; SDU071 |
| 英文同义词 | SDU-071; SDU 071; SDU071 |
| 分子式 | C28H25N3O2 |
| 分子量 | 435.52 |
| Smile | COC(C=C1)=CC=C1NC2=CC(CNC3=CC=C(OC)C=C3)=NC4=C5C(C=CC=C5)=CC=C42 |
| InChiKey | ZWWQETFJXKSVFP-UHFFFAOYSA-N |
| InChi | InChI=1S/C28H25N3O2/c1-32-23-12-8-20(9-13-23)29-18-22-17-27(30-21-10-14-24(33-2)15-11-21)26-16-7-19-5-3-4-6-25(19)28(26)31-22/h3-17,29H,18H2,1-2H3,(H,30,31) |
| Cas号 | 3036109-10-8 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 类白色固体 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 0-4℃，可保存几天到几周；-20℃，可保存 几个月。 |
| 可溶性 | 溶于DMSO等有机溶剂 |
| 处理方式 | |
| 运输条件 | 可以在室温下进行运输。 |
| 海关编码 |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Novel BRD4-p53 Inhibitor SDU-071 Suppresses Proliferation and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells
Shumei Wang, Kang Lei, Hsien-Tsung Lai, Tingting Liu, Lupei Du, Shwu-Yuan Wu, Xiaohan Ye, Cheng-Ming Chiang, and Minyong Li
ACS Pharmacology & Translational Science 2024 7 (4), 1178-1190
DOI: 10.1021/acsptsci.4c00057
