SEA0400 is a Na+/Ca2+ exchanger 1 inhibitor. SEA0400 prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. SEA0400 reduces calcium overload induced by ischemia and reperfusion in mouse ventricular myocytes. SEA0400 attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia. SEA0400, preserves cardiac function and high-energy phosphates against ischemia/reperfusion injury.
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化学信息
名称 | SEA0400 |
Iupac 化学名称 | 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline |
同义词 | C21H19F2NO3 |
英文同义词 | C21H19F2NO3 |
分子式 | C21H19F2NO3 |
分子量 | 371.3838 |
Smile | FC1=C(C=C(C=C1)F)COC1=CC=C(OC2=C(N)C=C(C=C2)OCC)C=C1 |
InChiKey | YSUBLPUJDOWYDP-UHFFFAOYSA-N |
InChi | InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3 |
Cas号 | 223104-29-8 |
相关CAS号 | |
外观性状 | Solid powder |
纯度 | 98% by HPLC |
存储 | -20 ºC for 3 years |
可溶性 | Soluble in DMSO |
处理方式 | |
运输条件 | Shipped under ambient temperature |
海关编码 | |
Targets | |
Mechanism | |
Cell study | |
Animal study | |
Clinical study | |