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SEW2871

编号: 20604
Cas号: 256414-75-2
纯度: 98% Min.

SEW2871 is a S1P1 agonist (sphingosine-1-phosphate type 1 receptor agonist). SEW2871 improves cognitive function in Alzheimer's disease model rats. SEW2871 prolongs heterotopic heart allograft survival in mice. SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. SEW2871 prolongs heterotopic heart allograft survival in mice.

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化学信息

名称SEW2871
Iupac 化学名称 5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole
同义词SEW2871; SEW2871; SEW2871.
英文同义词SEW2871; SEW2871; SEW2871.
分子式C20H10F6N2OS
分子量440.36
SmileFC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F
InChiKeyOYMNPJXKQVTQTR-UHFFFAOYSA-N
InChiInChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
Cas号256414-75-2
相关CAS号

订购信息

包装价格库存纯度备货期
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Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状固体粉末
纯度98% Min.
存储短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
可溶性溶于DMSO
处理方式
运输条件作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Zou L, Ke L, Wu C, Tong Z, Li W, Li N, Li J. SEW2871 Alleviates the Severity of Caerulein-Induced Acute Pancreatitis in Mice. Biol Pharm Bull. 2015;38(7):1012-9. doi: 10.1248/bpb.b15-00043. Epub 2015 May 2. PubMed PMID: 25948069.

2: Ni Q, Yuan B, Liu T, Lan F, Luo X, Lu X, Huang P, Dai L, Jin X, Yin H. Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice. Int Immunopharmacol. 2015 May;26(1):37-42. doi: 10.1016/j.intimp.2015.03.004. Epub 2015 Mar 13. PubMed PMID: 25776899.

3: Dong J, Wang H, Zhao J, Sun J, Zhang T, Zuo L, Zhu W, Gong J, Li Y, Gu L, Li J. SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice. Immunol Res. 2015 Mar;61(3):303-11. doi: 10.1007/s12026-015-8625-5. PubMed PMID: 25588868.

4: Dong J, Wang H, Wu G, Zhao J, Zhang L, Zuo L, Zhu W, Gong J, Li Y, Gu L, Li J. Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clin Exp Immunol. 2014 Jul;177(1):94-101. doi: 10.1111/cei.12304. PubMed PMID: 24611843; PubMed Central PMCID: PMC4089158.

5: Asle-Rousta M, Oryan S, Ahmadiani A, Rahnema M. Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer's disease model rats. EXCLI J. 2013 Jun 3;12:449-61. eCollection 2013. PubMed PMID: 26417237; PubMed Central PMCID: PMC4566907.

6: Rolin J, Sand KL, Knudsen E, Maghazachi AA. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010 Apr;59(4):575-86. doi: 10.1007/s00262-009-0775-7. Epub 2009 Oct 13. PubMed PMID: 19823820.

7: Tsukada YT, Sanna MG, Rosen H, Gottlieb RA. S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. J Cardiovasc Pharmacol. 2007 Dec;50(6):660-9. PubMed PMID: 18091583.

8: Lien YH, Yong KC, Cho C, Igarashi S, Lai LW. S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure. Kidney Int. 2006 May;69(9):1601-8. PubMed PMID: 16572108.

化学结构

20604 - SEW2871 | CAS 256414-75-2

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