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SEW2871

Catalog No: 20604
CAS Number: 256414-75-2
Purity: 98% Min.

SEW2871 is a S1P1 agonist (sphingosine-1-phosphate type 1 receptor agonist). SEW2871 improves cognitive function in Alzheimer's disease model rats. SEW2871 prolongs heterotopic heart allograft survival in mice. SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. SEW2871 prolongs heterotopic heart allograft survival in mice.

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Chemical Information

NameSEW2871
Iupac Chemical Name 5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole
SynonymsSEW2871; SEW2871; SEW2871.
英文同义词SEW2871; SEW2871; SEW2871.
Molecular FormulaC20H10F6N2OS
Molecular Weight440.36
SmileFC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F
InChiKeyOYMNPJXKQVTQTR-UHFFFAOYSA-N
InChiInChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
CAS Number256414-75-2
相关CAS号

Ordering Information

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外观性状固体粉末
Purity98% Min.
Storage短期(几天到几周)为0-4摄氏度,长期(几个月)为-20摄氏度
Solubility溶于DMSO
处理方式
Shipping Condition作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周.
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Zou L, Ke L, Wu C, Tong Z, Li W, Li N, Li J. SEW2871 Alleviates the Severity of Caerulein-Induced Acute Pancreatitis in Mice. Biol Pharm Bull. 2015;38(7):1012-9. doi: 10.1248/bpb.b15-00043. Epub 2015 May 2. PubMed PMID: 25948069.

2: Ni Q, Yuan B, Liu T, Lan F, Luo X, Lu X, Huang P, Dai L, Jin X, Yin H. Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice. Int Immunopharmacol. 2015 May;26(1):37-42. doi: 10.1016/j.intimp.2015.03.004. Epub 2015 Mar 13. PubMed PMID: 25776899.

3: Dong J, Wang H, Zhao J, Sun J, Zhang T, Zuo L, Zhu W, Gong J, Li Y, Gu L, Li J. SEW2871 protects from experimental colitis through reduced epithelial cell apoptosis and improved barrier function in interleukin-10 gene-deficient mice. Immunol Res. 2015 Mar;61(3):303-11. doi: 10.1007/s12026-015-8625-5. PubMed PMID: 25588868.

4: Dong J, Wang H, Wu G, Zhao J, Zhang L, Zuo L, Zhu W, Gong J, Li Y, Gu L, Li J. Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clin Exp Immunol. 2014 Jul;177(1):94-101. doi: 10.1111/cei.12304. PubMed PMID: 24611843; PubMed Central PMCID: PMC4089158.

5: Asle-Rousta M, Oryan S, Ahmadiani A, Rahnema M. Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer's disease model rats. EXCLI J. 2013 Jun 3;12:449-61. eCollection 2013. PubMed PMID: 26417237; PubMed Central PMCID: PMC4566907.

6: Rolin J, Sand KL, Knudsen E, Maghazachi AA. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol Immunother. 2010 Apr;59(4):575-86. doi: 10.1007/s00262-009-0775-7. Epub 2009 Oct 13. PubMed PMID: 19823820.

7: Tsukada YT, Sanna MG, Rosen H, Gottlieb RA. S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. J Cardiovasc Pharmacol. 2007 Dec;50(6):660-9. PubMed PMID: 18091583.

8: Lien YH, Yong KC, Cho C, Igarashi S, Lai LW. S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure. Kidney Int. 2006 May;69(9):1601-8. PubMed PMID: 16572108.

Chemical Structure

20604 - SEW2871 | CAS 256414-75-2

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