SJ-172550
SJ-172550, also known as MDMX Inhibitor II, is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | SJ-172550 |
|---|---|
| Iupac 化学名称 | methyl (Z)-2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)phenoxy)acetate |
| 同义词 | SJ-172550; SJ 172550; SJ172550. MDMX Inhibitor II. |
| 英文同义词 | SJ-172550; SJ 172550; SJ172550. MDMX Inhibitor II. |
| 分子式 | C22H21ClN2O5 |
| 分子量 | 428.87 |
| Smile | ClC1=CC(/C=C2C(N(C3=CC=CC=C3)N=C\2C)=O)=CC(OCC)=C1OCC(OC)=O |
| InChiKey | RKKFQJXGAQWHBZ-YVLHZVERSA-N |
| InChi | InChI=1S/C22H21ClN2O5/c1-4-29-19-12-15(11-18(23)21(19)30-13-20(26)28-3)10-17-14(2)24-25(22(17)27)16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3/b17-10- |
| Cas号 | 431979-47-4 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
| 外观性状 | 固体粉末 |
|---|---|
| 纯度 | 98% Min. |
| 存储 | 短期（几天到几周）为0-4摄氏度，长期（几个月）为-20摄氏度 |
| 可溶性 | 溶于DMSO |
| 处理方式 | |
| 运输条件 | 作为非危险化学品在环境温度下装运。这种产品在正常运输和海关工作期间可以稳定几周. |
| 海关编码 |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One. 2012;7(6):e37518. doi: 10.1371/journal.pone.0037518. Epub 2012 Jun 4. PubMed PMID: 22675482; PubMed Central PMCID: PMC3366986.
2: Leão M, Gomes S, Bessa C, Soares J, Raimundo L, Monti P, Fronza G, Pereira C, Saraiva L. Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules. Exp Cell Res. 2015 Jan 1;330(1):164-77. doi: 10.1016/j.yexcr.2014.09.028. Epub 2014 Sep 28. PubMed PMID: 25265062.
3: Lemos A, Leão M, Soares J, Palmeira A, Pinto M, Saraiva L, Sousa ME. Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction. Med Res Rev. 2016 Sep;36(5):789-844. doi: 10.1002/med.21393. Epub 2016 Jun 15. Review. PubMed PMID: 27302609.
4: Noushini S, Alipour E, Emami S, Safavi M, Ardestani SK, Gohari AR, Shafiee A, Foroumadi A. Synthesis and cytotoxic properties of novel (E)-3-benzylidene-7-methoxychroman-4-one derivatives. Daru. 2013 Apr 12;21(1):31. doi: 10.1186/2008-2231-21-31. PubMed PMID: 23587260; PubMed Central PMCID: PMC3668990.
5: Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15. PubMed PMID: 20080970; PubMed Central PMCID: PMC2856285.
6: Leão M, Gomes S, Soares J, Bessa C, Maciel C, Ciribilli Y, Pereira C, Inga A, Saraiva L. Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity. FEBS J. 2013 Dec;280(24):6498-507. doi: 10.1111/febs.12552. Epub 2013 Oct 23. PubMed PMID: 24119020.
7: Soares J, Raimundo L, Pereira NA, dos Santos DJ, Pérez M, Queiroz G, Leão M, Santos MM, Saraiva L. A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins. Pharmacol Res. 2015 May-Jun;95-96:42-52. doi: 10.1016/j.phrs.2015.03.006. Epub 2015 Mar 23. PubMed PMID: 25814188.
