SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.
SJB3-019A also increased the levels of Ub-FANCD2 and Ub-PCNA, and decreased the HR activity .
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名称 | SJB3-019A |
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Iupac 化学名称 | SJB3-019A |
分子式 | C16H8N2O3 |
分子量 | 276.25 |
Smile | C[Si](C)(C)CSCCl |
InChiKey | IKWIERSJEROYFH-UHFFFAOYSA-N |
InChi | InChI=1S/C5H13ClSSi/c1-8(2,3)5-7-4-6/h4-5H2,1-3H3 |
Cas号 | 2070015-29-9 |
MDL | MFCD17013410 |
相关CAS号 |
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